Locally advanced rectal cancer and total neoadjuvant therapy - 1
Total neoadjuvant therapy, whether induction chemotherapy or consolidation chemotherapy is being considered in a lot of trials currently to manage Locally advanced rectal cancer (LARC). LARC is a type of cancer that has spread beyond the rectal wall but has not yet metastasized to other parts of the body. Total neoadjuvant therapy (TNT) is a treatment approach that involves administering chemotherapy and radiation therapy before surgery.
There are two main approaches to chemotherapy in TNT for LARC: induction chemotherapy and consolidation chemotherapy. Induction chemotherapy is given before radiation therapy, while consolidation chemotherapy is given after radiation therapy but before surgery. Both approaches have their advantages and disadvantages, and the choice between them depends on the individual patient's circumstances and the preferences of their healthcare team.
Induction chemotherapy can help to reduce the size of the tumor and make it easier to remove during surgery. It can also help to identify patients who may not respond well to radiation therapy, allowing for treatment modifications or alternative approaches. However, induction chemotherapy may delay the start of radiation therapy and can be associated with increased toxicity.
Consolidation chemotherapy, on the other hand, can help to eradicate any remaining cancer cells after radiation therapy and reduce the risk of recurrence. It can also help to identify patients who may benefit from additional treatment, such as targeted therapy or immunotherapy.
Overall, the choice between induction and consolidation chemotherapy depends on the individual patient's circumstances and the preferences of their healthcare team. Both approaches can be effective in reducing the size of the tumor and improving outcomes for patients with LARC. It is important for patients to discuss the benefits and risks of each approach with their healthcare team and make an informed decision based on their individual needs and circumstances.